Post-Doc // development of microfluidic chips and cuvettes for the mid-infrared spectroscopic investigation of biological fluids and cells for medical purposes
In collaboration between the Center for Molecular Fingerprinting (CMF, mukkozpont.hu) and the Ludwig-Maximilians-Universität (LMU) in Munich (www.attoworld.de/bird) we combine cutting-edge femtosecond laser technologies with novel molecular fingerprinting techniques to advance a new type of mid-infrared spectroscopy on the electric-field level. The consortium of highly interdisciplinary team of laser physicists, data scientists, molecular biologists and clinical personnel is focusing on demonstration how state-of-the-art laser-based field-resolved infrared spectroscopy (FRS) that generates ultrashort light pulses , can be utilized for health monitoring and disease detection (https://www.lasers4life.de/). … more
We are seeking for candidates interested in development and implementation of microfluidic platforms that enable spatio-temporal control of microfluidic-chamber/cuvette flow through systems (microfluidic chips) and its integration with laser-based field-resolved spectroscopy.This will allow infrared spectroscopy to be effectively applied to specimens in aqueous environments or liquids to obtain label-free chemical information about the sample for the investigation of cells as well as human blood-based bioliquids. The goal is to support and further develop the following three projects:
- Infrared fingerprinting of human blood-based bioliquids for disease detection;
- Coupling of liquid chromatography to infrared spectroscopy to increase the specificity of the above-mentioned application;
- High-throughput infrared measurements of cells (i.e. label-free flow-cytometry).
The workplace is at the Laboratory for Extreme Photonics (LEX Photonics; www.lex-photonics.de) of the LMU at the research campus Garching, north of Munich. The candidate will work in a highly international and interdisciplinary team in direct collaboration with laser scientists, engineers, developing the next generation laser-based infrared spectrometers, as well as the molecular scintists providing the biological samples.
 Pupeza, I., Huber, M., et al.
Field-resolved infrared spectroscopy of biological systems. Nature 577, 52–59 (2020).
- the main subject will be to develop, implement and experimentally apply a microfluidic platform that enables spatio-temporal control of microfluidic-chamber/cuvette flow through systems (microfluidic chips) and its integration with laser-based field-resolved spectroscopy;
- setting up simple (optical) measurement setups;
- writing and presenting the results of scientific work;
- identification and establishment of potential collaborations that can help in the above-mentioned tasks.
- doctoral degree (or equivalent) in microfluidics, microengineering, physics, biology or chemistry or related fields
- experience with microfluidic engineering;
- experience in setup and adjustment of optical systems;
- ability to work in an international environment;
- user-level computer management skills;
- strong motivaton, ability to work independently but also well equipped for collaboration in this multidisciplinary project;
- ability to quickly adapt to a changing environment;
- team spirited and like to share your scientific issues with a multicultural and diverse environment;
- quick learning and good communication skills, excellence in expressing in English, both orally and in written form, command of German and / or Hungarian is advantageous;
- excellent planning skills, with responsibile mindset while keeping high level of flexibility and accuracy.
- a unique possibility to work at highly cross-disciplinary field, at the forefront of laser sciences shaping the future of biomedical diagnostics;
- a broad range of activities in a dynamically evolving second-to-none endeavor and professional environment;
- ample opportunities for improving professional skills and qualifications – including professional training and workshops;
- the position is initially limited to two years with the possibility of an extension.
We are interested in filling the positions as soon as possible, thus the applications are continuously evaluated until the position is filled.
Please send a brief cover letter explaining your interest in the post and your CV and contact information of two references to Dr. Mihaela Zigman (email@example.com).